ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate

Base Information

• Chemical Name: ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate
• CAS No.: 777857-40-6
• Molecular Formula: C₂₄H₂₄O₆
• Molecular Weight: 408.451

Synonyms:ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate

Chemical Property of ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate

Chemical Property:

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Technology Process of ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate

There total 3 articles about ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-(7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)propionic acid ethyl ester (5969-19-7) + 2-bromo-1-phenyl-1-propanone (2114-00-3) → ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate (777857-40-6)

Guidance literature:

With sodium carbonate; In acetone; at 50 - 56 ℃;

DOI:10.1023/B:RUBI.0000030137.88504.10

Reference yield:

diethyl 2-acetylglutarate (1501-06-0) → ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate (777857-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / HCl / ethanol / 20 °C

2: 71 percent / Na₂CO₃ / acetone / 50 - 56 °C

With hydrogenchloride; sodium carbonate; In ethanol; acetone; 1: Pechmann condensation / 2: Williamson reaction;

DOI:10.1023/B:RUBI.0000030137.88504.10

Reference yield:

recorcinol (108-46-3) → ethyl 3-[4'-methyl-7'-(1''-methyl-2''-oxo-2''-phenylethoxy)-2'-oxochromen-3'-yl]propanoate (777857-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / HCl / ethanol / 20 °C

2: 71 percent / Na₂CO₃ / acetone / 50 - 56 °C

With hydrogenchloride; sodium carbonate; In ethanol; acetone; 1: Pechmann condensation / 2: Williamson reaction;

DOI:10.1023/B:RUBI.0000030137.88504.10

upstream raw materials:

3-(7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)propionic acid ethyl ester

2-bromo-1-phenyl-1-propanone

diethyl 2-acetylglutarate

recorcinol

Downstream raw materials:

3-(2',5'-dimethyl-7'-oxo-3'-phenylfuro[3,2-g]chromen-6'-yl)propanoic acid

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