trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

Base Information

Chemical Name:trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol
CAS No.:1578240-69-3
Molecular Formula:C₇H₁₀Br₂O
Molecular Weight:269.964
Hs Code.:

Synonyms:trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

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Chemical Property of trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

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Technology Process of trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

There total 1 articles about trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1578240-69-3
trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: cetyltrimethylammonim bromide; sodium hydroxide / water / 24 h / 20 °C

2.1: diisobutylaluminium hydride / toluene / -78 - 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere

With sodium tetrahydroborate; cetyltrimethylammonim bromide; diisobutylaluminium hydride; sodium hydroxide; In ethanol; water; toluene;
DOI:10.1021/ja5012542

Reference yield:

: 1578240-69-3
trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

: C₂₅H₃₀N₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 1 h / 0 °C

2: titanium(IV) isopropylate; ethylmagnesium bromide / diethyl ether / 6 h / 0 °C / Inert atmosphere

3: potassium tert-butylate / dimethyl sulfoxide / 4 h / 0 °C / Inert atmosphere

4: [D₃]acetonitrile / pH 7.4 / Inert atmosphere; UV-irradiation

With titanium(IV) isopropylate; ethylmagnesium bromide; potassium tert-butylate; toluene-4-sulfonic acid; In diethyl ether; [D₃]acetonitrile; dimethyl sulfoxide;
DOI:10.1021/ja5012542

Reference yield:

: 1578240-69-3
trans-(1,1-dibromospiro[2.3]hexan-5-yl)methanol

: C₃₂H₄₂N₃O₈S^(1-)*Na⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 1 h / 0 °C

2: titanium(IV) isopropylate; ethylmagnesium bromide / diethyl ether / 6 h / 0 °C / Inert atmosphere

3: potassium tert-butylate / dimethyl sulfoxide / 4 h / 0 °C / Inert atmosphere

4: [D₃]acetonitrile; aq. phosphate buffer / pH 7.5 / UV-irradiation

With titanium(IV) isopropylate; ethylmagnesium bromide; potassium tert-butylate; toluene-4-sulfonic acid; In aq. phosphate buffer; diethyl ether; [D₃]acetonitrile; dimethyl sulfoxide;
DOI:10.1021/ja5012542