(3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one

Base Information

• Chemical Name: (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one
• CAS No.: 253445-86-2
• Molecular Formula: C₂₀H₁₉N₃O₆S
• Molecular Weight: 429.453
• Mol file: 253445-86-2.mol

Synonyms:(3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one

Chemical Property of (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one

There total 1 articles about (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

acetic anhydride (108-24-7) + ((S)-3-Amino-2-oxo-azetidin-1-yl)-phenylsulfanyl-acetic acid 4-nitro-benzyl ester; compound with trifluoro-acetic acid → (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one (253445-86-2)

Guidance literature:

With potassium carbonate; In water; acetonitrile; at 20 ℃; for 0.5h; pH=7;

DOI:10.1016/S0040-4020(99)00819-4

Reference yield: 71.0%

N-ethylmorpholine; (100-74-3) + (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one (253445-86-2) → ((S)-3-Acetylamino-2-oxo-azetidin-1-yl)-phenylsulfanyl-acetic acid; compound with 4-ethyl-morpholine

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; at 20 ℃; for 2h; under 2068.59 Torr;

DOI:10.1016/S0040-4020(99)00819-4

Reference yield:

(3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one (253445-86-2) → ((S)-3-Acetylamino-2-oxo-azetidin-1-yl)-phenylsulfanyl-acetic acid

Guidance literature:

In phosphate buffer; acetonitrile; Further Variations:; pH-values; Solvents; Kinetics;

DOI:10.1016/S0040-4020(99)00819-4

upstream raw materials:

acetic anhydride