2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide

Base Information

• Chemical Name: 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide
• CAS No.: 257290-73-6
• Molecular Formula: C₁₉H₁₇BrN₄O₃S
• Molecular Weight: 461.339

Synonyms:2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide

Chemical Property of 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide

Chemical Property:

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Technology Process of 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide

There total 2 articles about 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-methyl-N-(pyrimidin-2-yl)benzenesulfonamide (16699-14-2) + α-bromo-(4-bromophenyl)acetamide (251366-61-7) → 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide (257290-73-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1055/s-1999-3640

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide (257290-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridine / 2 h / 0 °C

2: 70 percent / diisopropylethylamine / dimethylformamide / 16 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1: Tosylation / 2: Substitution;

DOI:10.1055/s-1999-3640

Reference yield: 80.0%

trifluoroacetic anhydride (407-25-0) + 2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide (257290-73-6) → N-[3-(4-bromo-phenyl)-imidazo[1,2-a]pyrimidin-2-yl]-2,2,2-trifluoro-acetamide

Guidance literature:

In dichloromethane; for 4h; Heating;

DOI:10.1055/s-1999-3640

upstream raw materials:

4-methyl-N-(pyrimidin-2-yl)benzenesulfonamide

α-bromo-(4-bromophenyl)acetamide

p-toluenesulfonyl chloride

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