(E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

Base Information

Chemical Name:(E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid
CAS No.:1365887-96-2
Molecular Formula:C₂₇H₂₄N₂O₃
Molecular Weight:424.499
Hs Code.:

Synonyms:(E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

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Chemical Property of (E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

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Technology Process of (E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

There total 6 articles about (E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₈N₂O₃

: 1365887-96-2
(E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00054

Reference yield:

: C₃₄H₃₆N₂O₄

: 1365887-96-2
(E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water; ethanol / Reflux

2: lithium hydroxide / tetrahydrofuran; water; ethanol / 20 °C

With hydrogenchloride; lithium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/acs.jmedchem.5b00054

Reference yield:

: 1365889-00-4
5-(but-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1365887-96-2
(E)-3-(4-((E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-en-1-yl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis(benzonitrile)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide; water / 45 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; water; ethanol / Reflux

3: lithium hydroxide / tetrahydrofuran; water; ethanol / 20 °C

With hydrogenchloride; bis(benzonitrile)palladium(II) dichloride; potassium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00054