4-fluoro-3-dibromomethylanisole

Base Information

• Chemical Name: 4-fluoro-3-dibromomethylanisole
• CAS No.: 347176-55-0
• Molecular Formula: C₈H₇Br₂FO
• Molecular Weight: 297.949
• Mol file: 347176-55-0.mol

Synonyms:4-fluoro-3-dibromomethylanisole

Chemical Property of 4-fluoro-3-dibromomethylanisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-3-dibromomethylanisole

There total 1 articles about 4-fluoro-3-dibromomethylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluoro-3-methylanisol (2338-54-7) → 4-fluoro-3-dibromomethylanisole (347176-55-0)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; Heating;

DOI:10.1016/S0968-0896(00)00286-8

Reference yield: 82.0%

4-fluoro-3-dibromomethylanisole (347176-55-0) → 2-fluoro-5-methoxybenzaldehyde (105728-90-3)

Guidance literature:

With sodium hydrogencarbonate; for 32h;

DOI:10.1016/S0968-0896(00)00286-8

Reference yield:

4-fluoro-3-dibromomethylanisole (347176-55-0) → threo-2-amino-1-(5-benzyloxy-2-fluorophenyl)-1-propanol

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / aq. NaHCO₃ / 32 h

2: 38 percent / BBr₃ / CH₂Cl₂ / -70 °C

3: 83 percent / K₂CO₃ / dimethylformamide / 3 h / 110 °C

4: 36 percent / aq. NaOH / methanol / 1.33 h / 0 °C

5: 40 percent / aq. HCO₂H; H₂ / Raney nickel / methanol / 20 °C

With sodium hydroxide; formic acid; hydrogen; boron tribromide; sodium hydrogencarbonate; potassium carbonate; nickel; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(00)00286-8

upstream raw materials:

4-fluoro-3-methylanisol

Downstream raw materials:

2-fluoro-5-methoxybenzaldehyde

methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate

5-benzyloxy-2-fluorobenzaldehyde

5-benzyloxy-2-N,N-dimethylaminobenzaldehyde

Refernces