Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate

Base Information

• Chemical Name: Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate
• CAS No.: 1111301-40-6
• Molecular Formula: C₁₇H₂₀N₂O₄S₂
• Molecular Weight: 380.489
• Mol file: 1111301-40-6.mol

Synonyms:Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate

Chemical Property of Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate

There total 1 articles about Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) + 3-Methyl-4-(pyrrolidin-1-yl)benzenesulfonic acid (1111301-37-1) → Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate (1111301-40-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate (1111301-40-6) → 3-(3-Methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylic acid (1111301-35-9)

Guidance literature:

Methyl 3-(3-methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 16h;

With hydrogenchloride; In water;

upstream raw materials:

Methyl 3-aminothiophene-2-carboxylate

3-Methyl-4-(pyrrolidin-1-yl)benzenesulfonic acid

Downstream raw materials:

3-(3-Methyl-4-(pyrrolidin-1-yl)phenylsulfonamido)thiophene-2-carboxylic acid