4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester

Base Information

• Chemical Name: 4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester
• CAS No.: 1061748-86-4
• Molecular Formula: C₂₀H₁₉N₃O₆
• Molecular Weight: 397.387

Synonyms:4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester

Chemical Property of 4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester

There total 1 articles about 4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester (1061748-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / PPh₃, diethyl azidodicarboxylate / dimethylformamide / a) from 0 deg C to RT, 1 h, b) RT, 30 min

2: 1.) MeMgCO₃, CO₂ / 1.) DMF, 1.5 h, 2.) DMF, 110 deg C, 3 h

With carbon dioxide; MeMgCO₃; triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00018a016

Reference yield:

4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester (1061748-86-4) → 4-{1-[2-(4-Amino-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester; hydrochloride

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00018a016

Reference yield:

4-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-benzoic acid methyl ester (1061748-86-4) → 4-(1-{2-[3-(2-Amino-ethyl)-1H-indol-5-yl]-ethyl}-2,5-dioxo-imidazolidin-4-ylmethyl)-benzoic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate

2: 1.) aq. HCl, NaNO₂, 2.) SnCl₂ / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h

3: ethanol; H₂O / 2 h / Heating

With hydrogenchloride; hydrogen; tin(ll) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; water; ethyl acetate;

DOI:10.1021/jm00018a016

upstream raw materials:

2-(4-nitrophenyl)ethanol

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