Technology Process of (3S,5R)-3-(4-methoxybenzyloxy)-5-(methoxymethoxy)oct-7-en-1-ol
There total 12 articles about (3S,5R)-3-(4-methoxybenzyloxy)-5-(methoxymethoxy)oct-7-en-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
DOI:10.1039/c2ob25151e
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 4 h / 0 °C
1.2: 0 - 20 °C
2.1: toluene-4-sulfonic acid / dichloromethane / 3 h / 0 - 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 - 20 °C
4.1: 1H-imidazole / dichloromethane / 5 h / 0 - 20 °C
5.1: copper(II) choride dihydrate / acetonitrile / 0.5 h / 0 - 20 °C
6.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 1 h / 0 - 20 °C
7.1: potassium carbonate / methanol / 0.5 h / 0 - 20 °C
8.1: copper(l) iodide / tetrahydrofuran / 0.25 h / -20 °C
8.2: 0.5 h / -40 °C
9.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C
With
1H-imidazole; dmap; copper(l) iodide; copper(II) choride dihydrate; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; di(n-butyl)tin oxide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1039/c2ob25151e
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 5 h / 0 - 20 °C
2.1: copper(II) choride dihydrate / acetonitrile / 0.5 h / 0 - 20 °C
3.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 1 h / 0 - 20 °C
4.1: potassium carbonate / methanol / 0.5 h / 0 - 20 °C
5.1: copper(l) iodide / tetrahydrofuran / 0.25 h / -20 °C
5.2: 0.5 h / -40 °C
6.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C
With
1H-imidazole; dmap; copper(l) iodide; copper(II) choride dihydrate; tetrabutyl ammonium fluoride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1039/c2ob25151e
