N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide
CAS No.:1565828-01-4
Molecular Formula:C₃₃H₃₂F₃N₃O₅
Molecular Weight:607.629
Hs Code.:

N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

Synonyms:N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

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Chemical Property of N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

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Technology Process of N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

There total 6 articles about N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2975-41-9
2,3-dihydro-1H-inden-2-amine

: 2-((2S,4aS,12aR)-5-methyl-6-oxo-8-(4-(trifluoromethyl)benzamido)-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-2-yl)acetic acid

: 1565828-01-4
N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: C₃₀H₃₂F₃N₅O₅

: 1565828-01-4
N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: methyl 2-((2S,4aS,12aR)-8-amino-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-2-yl)acetate

: 1565828-01-4
N-((2S,4aS,12aR)-2-(2-((2,3-dihydro-1H-inden-2-yl)amino)-2-oxoethyl)-5-methyl-6-oxo-2,3,4,4a,5,6,12,12a-octahydrobenzo[b]pyrano[3,2-f][1,5]oxazocin-8-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dihydrogen peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/C8MD00297E