2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

Base Information

Chemical Name:2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine
CAS No.:133008-54-5
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

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Chemical Property of 2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

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Technology Process of 2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

There total 9 articles about 2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 133008-53-4
2-methyl-3-(benzyloxy)-5-((benzyloxy)methyl)pyridine-4-carboxylic acid

: 133008-54-5
2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

Guidance literature:: In methanol; diethyl ether; at 0 ℃;
DOI:10.1021/jo00008a071

Reference yield:

: 1136-52-3
(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

: 133008-54-5
2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 1) NaH / 1) THF, 30 min, reflux, 2) 4 h, reflux

2: 94 percent / 98percent formic acid / H₂O / 24 h / 50 °C

3: 83 percent / NaOMe / methanol / 0.33 h / Ambient temperature

4: 94 percent / pyridinium chlorochromate, NaOAc, 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / Ambient temperature

5: 82 percent / 1 M aq. KMnO₄, 5percent aq. sodium phosphate / methanol / 1 h / Ambient temperature

6: 89 percent / diethyl ether; methanol / 0 °C

With potassium permanganate; formic acid; 3 A molecular sieve; sodium methylate; sodium acetate; sodium hydride; sodium phosphate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo00008a071

Reference yield:

: 65-23-6
5-hydroxy-6-methyl-3,4-pyridinedimethanol

: 133008-54-5
2-methyl-3-(benzyloxy)-4-(methoxycarbonyl)-5-((benzyloxy)methyl)pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / p-TsOH / acetone / 16 h

2: 1) NaH / 1) THF, 30 min, reflux, 2) 4 h, reflux

3: 94 percent / 98percent formic acid / H₂O / 24 h / 50 °C

4: 83 percent / NaOMe / methanol / 0.33 h / Ambient temperature

5: 94 percent / pyridinium chlorochromate, NaOAc, 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / Ambient temperature

6: 82 percent / 1 M aq. KMnO₄, 5percent aq. sodium phosphate / methanol / 1 h / Ambient temperature

7: 89 percent / diethyl ether; methanol / 0 °C

With potassium permanganate; formic acid; 3 A molecular sieve; sodium methylate; sodium acetate; sodium hydride; toluene-4-sulfonic acid; sodium phosphate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo00008a071