N2-METHYLGUANOSINE

Base Information

• Chemical Name: N2-METHYLGUANOSINE
• CAS No.: 2140-77-4
• Molecular Formula: C₁₁H₁₅N₅O₅
• Molecular Weight: 297.271
• Mol file: 2140-77-4.mol

Synonyms:2-Methylguanosine;N2-Methylguanine riboside; N2-Methylguanosine

Chemical Property of N2-METHYLGUANOSINE

Chemical Property:

• Vapor Pressure: 3.99E-21mmHg at 25°C
• Melting Point: 233 °C (decomp)(Solv: water (7732-18-5))
• Refractive Index: 1.849
• Boiling Point: 709.5°Cat760mmHg
• PKA: 9.87±0.20(Predicted)
• Flash Point: 382.9°C
• PSA: 145.52000
• Density: 2g/cm³
• LogP: -2.15420
• Storage Temp.: −20°C

Purity/Quality:

97% ^*data from raw suppliers

N2-Methylguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N2-METHYLGUANOSINE

There total 15 articles about N2-METHYLGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-N-(p-Tolylthiomethyl)-guanosine (77312-37-9) → N2-Methylguanosine (2140-77-4)

Guidance literature:

With sodium tetrahydroborate; In dimethyl sulfoxide; at 100 ℃; for 1h;

DOI:10.1055/s-1980-29310

Reference yield: 73.0%

2',3',5'-Tri-O-acetyl-N2-methylguanosine (4395-48-6) → N2-Methylguanosine (2140-77-4)

Guidance literature:

With sodium hydroxide; In pyridine; for 0.333333h; Ambient temperature;

DOI:10.1021/jo00003a052

Reference yield: 70.0%

9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-(methylamino)-1,9-dihydro-6H-purin-6-one (5391-07-1) → N2-Methylguanosine (2140-77-4)

Guidance literature:

With formic acid;

DOI:10.1002/adsc.201100505

upstream raw materials:

2',3',5'-Tri-O-acetyl-N²-methylguanosine

2-N-(p-Tolylthiomethyl)-guanosine

tert-butyl peroxyacetate

G