methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Base Information

Chemical Name:methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate
CAS No.:1202889-88-0
Molecular Formula:C₂₆H₂₁ClN₂O₆
Molecular Weight:492.916
Hs Code.:

Synonyms:methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

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Chemical Property of methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

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Technology Process of methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

There total 9 articles about methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.1%

: 5555-51-1
(4-chlorobenzyl)oxyamine

: 1202889-60-8
4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid

: 1202889-88-0
methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Guidance literature:: 4-(6-cyano-4-(methoxycarbonyl)chroman-7-yloxy)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.333333h;

(4-chlorobenzyl)oxyamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

Reference yield:

: 1202889-76-6
methyl 6-cyano-7-fluorochroman-4-carboxylate

: 1202889-88-0
methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h

3.2: 0.5 h

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 113209-68-0
3,4-dihydro-7-fluoro-2H-1-benzopyran-4-one

: 1202889-88-0
methyl 7-(4-((4-chlorobenzyloxy)carbamoyl)phenoxy)-6-cyano-3,4-dihydro-2H-chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: zinc(II) iodide / 4 h / 20 °C

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water; acetic acid / 130 °C

3.1: sulfuric acid / tetrahydrofuran / 12 h / 55 °C

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

5.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere

6.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

8.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h

8.2: 0.5 h

With hydrogenchloride; N-Bromosuccinimide; oxalyl dichloride; tin(II) chloride dihdyrate; sulfuric acid; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; zinc(II) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;