benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate

Base Information

• Chemical Name: benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate
• CAS No.: 1364376-31-7
• Molecular Formula: C₂₂H₂₂I₂N₂O₄
• Molecular Weight: 632.237

Synonyms:benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate

Chemical Property of benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate

There total 6 articles about benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(S)-2-((tert-butoxycarbonyl)amino)-4-pentynoic acid benzyl ester (936242-42-1) + 3,4,5-triiodopyridine (1111241-52-1) → benzyl 5-{5'-[4''-(S)-benzyloxycarbonyl-4''-(tert-butoxycarbonyl)aminobut-1''-ynyl]-4'-iodopyridin-3'-yl}-2-(S)-[(tert-butoxycarbonyl)amino]pent-4-ynoate (1364376-34-0) + benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate (1364376-31-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15.5h; Inert atmosphere;

DOI:10.1039/c2cc17958j

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → benzyl 5-{5'-[4''-(S)-benzyloxycarbonyl-4''-(tert-butoxycarbonyl)aminobut-1''-ynyl]-4'-iodopyridin-3'-yl}-2-(S)-[(tert-butoxycarbonyl)amino]pent-4-ynoate (1364376-34-0) + benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate (1364376-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium acetate; sodium hydroxide / water / Reflux; Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: phosphorus tribromide / ethyl acetate / 4.5 h / 145 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere

3.2: 24 h / Inert atmosphere; Reflux

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium acetate; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; 4.1: Sonogashira coupling;

DOI:10.1039/c2cc17958j

Reference yield:

4-hydroxy-3,5-diiodopyridine (7153-08-4) → benzyl 5-{5'-[4''-(S)-benzyloxycarbonyl-4''-(tert-butoxycarbonyl)aminobut-1''-ynyl]-4'-iodopyridin-3'-yl}-2-(S)-[(tert-butoxycarbonyl)amino]pent-4-ynoate (1364376-34-0) + benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate (1364376-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphorus tribromide / ethyl acetate / 4.5 h / 145 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere; Reflux

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; 3.1: Sonogashira coupling;

DOI:10.1039/c2cc17958j

upstream raw materials:

pyridin-4-ol

(S)-2-((tert-butoxycarbonyl)amino)-4-pentynoic acid benzyl ester

3,4,5-triiodopyridine

4-hydroxy-3,5-diiodopyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1364376-31-7 benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-(4',5'-diiodopyridin-3'-yl)pent-4-ynoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send