kulokekahilide-2

Base Information

Chemical Name:kulokekahilide-2
CAS No.:761444-83-1
Molecular Formula:C₄₄H₆₇N₅O₁₀
Molecular Weight:826.043
Hs Code.:

Synonyms:kulokekahilide-2

Suppliers and Price of kulokekahilide-2

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of kulokekahilide-2

Chemical Property:

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Technology Process of kulokekahilide-2

There total 18 articles about kulokekahilide-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1009642-79-8
C₄₆H₇₁N₅O₁₀S

: 761444-83-1
kulokekahilide-2

Guidance literature:: With 2,6-dimethylpyridine; water; silver nitrate; In tetrahydrofuran; at 65 ℃; for 1.5h;
DOI:10.1016/j.tet.2011.10.094

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 761444-83-1
kulokekahilide-2

Guidance literature:: Multi-step reaction with 8 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 17 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 h / 20 °C

3: pyridine; pyridine hydrogenfluoride / tetrahydrofuran / 12 h / 40 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 0 - 20 °C

5: ammonium acetate; zinc / tetrahydrofuran; water / 22.5 h / 20 °C

6: diethylamine / acetonitrile / 4 h / 20 °C

7: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 23 h / 20 °C

8: 2,6-dimethylpyridine; water; silver nitrate / tetrahydrofuran / 1.5 h / 65 °C

With pyridine; 2,6-dimethylpyridine; dmap; 1-hydroxy-7-aza-benzotriazole; ammonium acetate; water; benzotriazol-1-ol; pyridine hydrogenfluoride; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2011.10.094

Reference yield:

: 1204215-22-4
C₈H₁₄Cl₃NO₂*ClH

: 761444-83-1
kulokekahilide-2

Guidance literature:: Multi-step reaction with 14 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 6 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 10 - 15 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 0 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 14 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 17 h / 20 °C

8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 h / 20 °C

9: pyridine; pyridine hydrogenfluoride / tetrahydrofuran / 12 h / 40 °C

10: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 0 - 20 °C

11: ammonium acetate; zinc / tetrahydrofuran; water / 22.5 h / 20 °C

12: diethylamine / acetonitrile / 4 h / 20 °C

13: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 23 h / 20 °C

14: 2,6-dimethylpyridine; water; silver nitrate / tetrahydrofuran / 1.5 h / 65 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; dmap; 1-hydroxy-7-aza-benzotriazole; ammonium acetate; water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; pyridine hydrogenfluoride; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2011.10.094