methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1609200-96-5
Molecular Formula:C₂₄H₂₄FNO₈S
Molecular Weight:505.521
Hs Code.:

methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Synonyms:methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 11 articles about methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609200-98-7
methyl (1aR,7bS)-5-[4-fluoro-2-(2-methoxymethoxymethylcyclopropyl)benzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609200-96-5
methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; water; methanol / 5 h / 20 °C

With pyridine; hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1609200-99-8
methyl (1aR,7bS)-5-(2-bromo-4-fluorobenzenesulfonylamino)-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609200-96-5
methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere; Microwave irradiation

2: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; water; methanol / 5 h / 20 °C

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; dichloromethane; water; 1: |Suzuki-Miyaura Coupling;

Reference yield:

: 1412976-22-7
methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609200-96-5
methyl (1aR,7bS)-5-{N-[4-fluoro-2-(2-hydroxymethylcyclopropyl)benzenesulfonyl]-N-(methoxycarbonyl)amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere; Microwave irradiation

3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; water; methanol / 5 h / 20 °C

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;