N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester
CAS No.:93394-78-6
Molecular Formula:C₅₄H₆₂N₆O₁₀S₂
Molecular Weight:1019.25
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

There total 12 articles about N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 93394-77-5
phenylalanyl-S-tritylcysteine methyl ester

: 93394-72-0
N-(tert-Butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycine

: 93394-78-6
N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

Reference yield:

: 556-33-2
glycine-glycine-glycine

: 93394-78-6
N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / 1N methanolic HCl / 3 h / Heating

2: 74 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole, N-methylmorpholine / tetrahydrofuran

3: 65 percent / NaOH

4: 69 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 93394-78-6
N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteinyl-glycyl-glycyl-glycyl-phenylalanyl-S-tritylcysteine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / triethylamine / H₂O; dioxane / 3 h

2: 82 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole, N-methylmorpholine / tetrahydrofuran / 1.) 1h, 0 deg C; 2.) 1h, room temperature

3: 67 percent / BF₃-OEt₂ / acetic acid

4: 69 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole

With 4-methyl-morpholine; boron trifluoride diethyl etherate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water; acetic acid;