[1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

Base Information

Chemical Name:[1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester
CAS No.:394734-85-1
Molecular Formula:C₂₁H₃₆N₂O₄
Molecular Weight:380.528
Hs Code.:

Synonyms:[1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

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Chemical Property of [1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

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Technology Process of [1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

There total 3 articles about [1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 394731-25-0
(S)-cyclohexyl-isobutoxycarbonylamino-acetic acid

: 394734-84-0
(1R,2S,5S)-(6,6-dimethyl-3-azabicyclo[3.1.0]hex-2-yl)methanol

: 394734-85-1
[1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile;
DOI:10.1021/jm060077j

Reference yield:

: (S)-cyclohexylglycine hydrochloride

: 394734-85-1
[1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃ / acetonitrile; H₂O / 17 h / 20 °C

2: 67 percent / HATU; diisopropylethylamine / acetonitrile

With potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; acetonitrile;
DOI:10.1021/jm060077j

Reference yield:

: 543-27-1
isobutyl chloroformate

: 394734-85-1
[1(S)-cyclohexyl-2-((1R,2S,5S)-2-hydroxymethyl-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]carbamic acid isobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃ / acetonitrile; H₂O / 17 h / 20 °C

2: 67 percent / HATU; diisopropylethylamine / acetonitrile

With potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; acetonitrile;
DOI:10.1021/jm060077j