2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

Base Information

Chemical Name:2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine
CAS No.:309967-57-5
Molecular Formula:C₄₈H₅₀N₇O₉PS
Molecular Weight:932.006
Hs Code.:

Synonyms:2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

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Chemical Property of 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

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Technology Process of 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

There total 6 articles about 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 309967-53-1
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-6-N-benzoyladenosine

: 309967-57-5
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1021/jo991097e

Reference yield:

: 148692-01-7
N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl adenosine

: 309967-57-5
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-tetrazole / CH₂Cl₂ / 2 h / 20 °C

2: S₈ / CS₂; pyridine / 2 h / 20 °C

3: 172 mg / (HF)*Py / pyridine / 0.17 h / 20 °C

4: 95 percent / pyridine / 4 h / 20 °C

With pyridine; 1H-tetrazole; sulfur; pyridine hydrogenfluoride; In pyridine; carbon disulfide; dichloromethane; 1: Substitution / 2: sulfurization / 3: desilylation / 4: tritylation;
DOI:10.1021/jo991097e

Reference yield:

: Thiophosphoric acid O-[(4aR,6R,7R,7aR)-6-(6-benzoylamino-purin-9-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl] ester O',O''-bis-(2-cyano-1,1-dimethyl-ethyl) ester

: 309967-57-5
2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 172 mg / (HF)*Py / pyridine / 0.17 h / 20 °C

2: 95 percent / pyridine / 4 h / 20 °C

With pyridine; pyridine hydrogenfluoride; In pyridine; 1: desilylation / 2: tritylation;
DOI:10.1021/jo991097e