6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

Base Information

• Chemical Name: 6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one
• CAS No.: 18730-32-0
• Molecular Formula: C₁₄H₇Br₂ClN₂OS
• Molecular Weight: 446.549

Synonyms:6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

Chemical Property of 6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

Chemical Property:

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Technology Process of 6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

There total 2 articles about 6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chlorophenyl isothiocyanate (2131-55-7) + 2-amino-3,5-dibromobenzoic acid (609-85-8) → 6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (18730-32-0)

Guidance literature:

In ethanol; Heating;

DOI:10.1021/je00049a031

Reference yield:

→ 6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (18730-32-0)

Guidance literature:

3,5-Dibromanthranilsaeure, p-Chlorphenylsenfoel;

DOI:10.1021/jm00308a067

Reference yield: 67.0%

6,8-dibromo-3-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one (18730-32-0) + 2-(4-methylphenoxy)acetyl chloride (15516-47-9) → p-Tolyloxy-thioacetic acid S-[6,8-dibromo-3-(4-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester (86149-04-4)

Guidance literature:

With sodium hydroxide; In ethanol; 2.) reflux, 6 h;

DOI:10.1002/ardp.19833160509

upstream raw materials:

4-Chlorophenyl isothiocyanate

2-amino-3,5-dibromobenzoic acid

Downstream raw materials:

o-Tolyloxy-thioacetic acid S-[6,8-dibromo-3-(4-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester

p-Tolyloxy-thioacetic acid S-[6,8-dibromo-3-(4-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester

(2-Chloro-phenoxy)-thioacetic acid S-[6,8-dibromo-3-(4-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester

(4-Chloro-phenoxy)-thioacetic acid S-[6,8-dibromo-3-(4-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-yl] ester

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