N-(3,4-Dichlorophenyl)maleamic acid, 97%

Base Information

• Chemical Name: N-(3,4-Dichlorophenyl)maleamic acid, 97%
• CAS No.: 21395-61-9
• Molecular Formula: C10H7 Cl2 N O3
• Molecular Weight: 260.076
• Mol file: 21395-61-9.mol

Synonyms:2-Butenoicacid, 4-[(3,4-dichlorophenyl)amino]-4-oxo-, (Z)-; Maleanilic acid,3',4'-dichloro- (6CI,8CI); (2Z)-4-[(3,4-dichlorophenyl)amino]-4-oxo-2-butenoicacid

Chemical Property of N-(3,4-Dichlorophenyl)maleamic acid, 97%

Chemical Property:

• Vapor Pressure: 2.44E-10mmHg at 25°C
• Melting Point: 205℃
• Refractive Index: 1.65
• Boiling Point: 488.1°Cat760mmHg
• Flash Point: 249°C
• PSA: 66.40000
• Density: 1.551g/cm³
• LogP: 2.64570

Purity/Quality:

99% ^*data from raw suppliers

N-(3,4-DICHLOROPHENYL)MALEAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,4-Dichlorophenyl)maleamic acid, 97%

There total 2 articles about N-(3,4-Dichlorophenyl)maleamic acid, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

maleic anhydride (108-31-6) + m,p-dichloroaniline (95-76-1) → N-(3,4-dichloro-phenyl)-maleamic acid (21395-61-9)

Guidance literature:

In chloroform; for 7h;

DOI:10.1081/SCC-120017198

Reference yield:

→ N-(3,4-dichloro-phenyl)-maleamic acid (21395-61-9)

Guidance literature:

Maleinsaeure-anhydrid, 3,4-Dichlor-anilin, CH2Cl2;

DOI:10.1002/hlca.19790620625

Reference yield: 41.0%

N-(3,4-dichloro-phenyl)-maleamic acid (21395-61-9) + (3E,5E)-3,5-dibenzylidenepiperidin-4-one hydrochloride → 4-(3,5-bisphenylmethylene-4-oxo-piperidin-1-yl)-4-oxo-but-2Z-enoic acid (3,4-dichlorophenyl)amide

Guidance literature:

N-(3,4-dichloro-phenyl)-maleamic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;

(3E,5E)-3,5-dibenzylidenepiperidin-4-one hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1081/SCC-120017198

upstream raw materials:

maleic anhydride

m,p-dichloroaniline

Downstream raw materials:

2-(3-anilino-4-oxo-2-thioxo-thiazolidin-5-yl)-N-(3,4-dichloro-phenyl)-acetamide

N-(3,4-dichloro-phenyl)-2-[3-(4-methyl-anilino)-4-oxo-2-thioxo-thiazolidin-5-yl]-acetamide

2-[3-(2,5-dichloro-anilino)-4-oxo-2-thioxo-thiazolidin-5-yl]-N-(3,4-dichloro-phenyl)-acetamide

C₁₁H₉Cl₂NO₃

Refernces

• 1、 -. "GHRELIN RECEPTOR MODULATORS". Page/Page column 39. . Retrieved 2008/12/07.