[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester
CAS No.:428880-38-0
Molecular Formula:C₆₂H₉₈IN₅O₁₃
Molecular Weight:1248.39
Hs Code.:

[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

Synonyms:[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

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Chemical Property of [8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

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Technology Process of [8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

There total 11 articles about [8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 150321-92-9
2,5-dioxotetrahydro-1H-1-pyrrolyl-7-methoxy-2-oxo-2H-3-chromene carboxylate

: 428880-37-9
{6-[(3-aminopropyl)-tert-butoxycarbonylamino]hexyl}-[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]carbamic acid tert-butyl ester

: 428880-38-0
[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm011067f

Reference yield:

: 104807-24-1
N,N'-bis(6-aminohexyl)-1,8-octanediamine

: 428880-38-0
[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: CF₃COOEt / methanol / 2 h / -80 - 0 °C

1.2: methanol / 1 h / 20 °C

1.3: 35 percent / 28percent aq. NH₄OH / methanol / 72 h / 20 °C / pH 11

2.1: 70 percent / methanol / 20 °C

3.1: 90 percent / H₂; 40percent aq. NaOH / Raney Ni / ethanol / 6 h / 20 °C / 775.74 Torr

4.1: 90 percent / methanol / 2 h / -80 - 0 °C

5.1: 56 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

6.1: toluene / 5 h / Heating

7.1: NaBH₄ / ethanol / 4 h / 0 °C

8.1: 45 percent / CHCl₃

9.1: 100 percent / 28percent aq. NH₄OH / methanol / 20 °C / pH 11

10.1: 72 percent / dimethylformamide / 20 °C

With sodium tetrahydroborate; ethyl trifluoroacetate,; hydrogen; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm011067f

Reference yield:

: 428879-87-2
{8-[(6-aminohexyl)-tert-butoxycarbonylamino]octyl}-(6-tert-butoxycarbonylaminohexyl)carbamic acid tert-butyl ester

: 428880-38-0
[8-(tert-butoxycarbonyl-{6-[tert-butoxycarbonyl-(5-iodo-2-methoxybenzyl)amino]hexyl}amino)octyl]-[6-(tert-butoxycarbonyl-{3-[(7-methoxy-2-oxo-2H-chromene-3-carbonyl)amino]propyl}amino)hexyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 70 percent / methanol / 20 °C

2: 90 percent / H₂; 40percent aq. NaOH / Raney Ni / ethanol / 6 h / 20 °C / 775.74 Torr

3: 90 percent / methanol / 2 h / -80 - 0 °C

4: 56 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

5: toluene / 5 h / Heating

6: NaBH₄ / ethanol / 4 h / 0 °C

7: 45 percent / CHCl₃

8: 100 percent / 28percent aq. NH₄OH / methanol / 20 °C / pH 11

9: 72 percent / dimethylformamide / 20 °C

With sodium tetrahydroborate; hydrogen; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm011067f