4-p-Tolylthiazol-2-ol

Base Information

• Chemical Name: 4-p-Tolylthiazol-2-ol
• CAS No.: 2103-90-4
• Molecular Formula: C10H9NOS
• Molecular Weight: 191.25
• Hs Code.: 2934100090
• European Community (EC) Number: 834-617-9
• Nikkaji Number: J1.721.643K
• Mol file: 2103-90-4.mol

Synonyms:4-p-tolylthiazol-2-ol;2103-90-4;4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-one;4-(4-methylphenyl)-1,3-thiazol-2(3H)-one;4-(4-methylphenyl)-3H-1,3-thiazol-2-one;4-(p-Tolyl)thiazol-2-ol;4-p-tolyl-3h-thiazol-2-one;2(3H)-Thiazolone, 4-(4-methylphenyl)-;SCHEMBL16414517;FKFCXWOMNWZZQG-UHFFFAOYSA-N;CAA10390;MFCD07658192;STK664871;AKOS003389126;4-(4-Methylphenyl)-4-thiazoline-2-one;LS-07849;CS-0216763;FT-0752002;EN300-59190;4-FLUORO-2-METHOXYBENZOICACIDMETHYLESTER;Z409413362

Chemical Property of 4-p-Tolylthiazol-2-ol

Chemical Property:

• PSA: 61.36000
• Density: 1.254 g/cm³
• LogP: 2.82410
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 191.04048508
• Heavy Atom Count: 13
• Complexity: 241

Purity/Quality:

99% ^*data from raw suppliers

4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CSC(=O)N2

Technology Process of 4-p-Tolylthiazol-2-ol

There total 6 articles about 4-p-Tolylthiazol-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thiocyanato-1-(4-tolyl)ethanone (6097-27-4) → 4-(p-tolyl)thiazol-2-ol (2103-90-4)

Guidance literature:

With hydrogenchloride;

Reference yield:

4-n-methylphenylacetylene (766-97-2) → 4-(p-tolyl)thiazol-2-ol (2103-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 9-(2-mesityl)-10-methylacridinium perchlorate / acetonitrile / 12 h / 20 °C / Irradiation

2: hydrogenchloride / water / 3 h / Reflux

With hydrogenchloride; 9-(2-mesityl)-10-methylacridinium perchlorate; In water; acetonitrile;

DOI:10.1039/C9OB00054B

Reference yield:

2-thiocyanato-1-(4-tolyl)ethanone (6097-27-4) → 4-(4-methylphenyl)-2-oxo-thiazole (2103-90-4)

Guidance literature:

With sulfuric acid; acetic acid;

upstream raw materials:

2-thiocyanato-1-(4-tolyl)ethanone

p-methylphenacyl chloride

4-n-methylphenylacetylene

Downstream raw materials:

3-Methyl-4-p-tolyl-3H-thiazol-2-one

2-Methoxy-4-p-tolyl-thiazole

C₃₅H₃₆N₂O₇S₂