2 4-DIISOPROPYLIODOBENZENE

Base Information

• Chemical Name: 2 4-DIISOPROPYLIODOBENZENE
• CAS No.: 2100-20-1
• Molecular Formula: C12H17 I
• Molecular Weight: 288.171
• Hs Code.: 2903999090
• Mol file: 2100-20-1.mol

Synonyms:Benzene,2-iodo-1,4-diisopropyl- (7CI,8CI); 1,4-Diisopropyl-2-iodobenzene

Chemical Property of 2 4-DIISOPROPYLIODOBENZENE

Chemical Property:

• PSA: 0.00000
• LogP: 4.53800

Purity/Quality:

97% ^*data from raw suppliers

2 4-DIISOPROPYLIODOBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2 4-DIISOPROPYLIODOBENZENE

There total 1 articles about 2 4-DIISOPROPYLIODOBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,4-bis(1-methylethyl)benzene (100-18-5) → 2-iodo-1,4-diisopropylbenzene (2100-20-1)

Guidance literature:

With iodine; Selectfluor; In acetonitrile; at 60 ℃; for 15h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03557

Reference yield: 84.0%

pent-1-yn-5-ol (5390-04-5) + 2-iodo-1,4-diisopropylbenzene (2100-20-1) → C17H24O

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03557

Reference yield:

2-iodo-1,4-diisopropylbenzene (2100-20-1) → C17H24O + C17H24O

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere

2: Zeise's dimer; tris(pentafluorophenyl)phosphine / toluene / 0.5 h / 23 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Zeise's dimer; triethylamine; tris(pentafluorophenyl)phosphine; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.orglett.9b03557

upstream raw materials:

1,4-bis(1-methylethyl)benzene

Downstream raw materials:

4-Iodo-2,5-diisopropyl-benzenesulfonamide

Refernces

• 1、 Stavber, Stojan,Kralj, Petra,Zupan, Marko. "Progressive direct iodination of sterically hindered alkyl substituted benzenes". . p. 1513 - 1518. Retrieved 2007/10/03.