methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

Base Information

Chemical Name:methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate
CAS No.:160012-73-7
Molecular Formula:C₂₅H₃₂N₂O₁₀S
Molecular Weight:552.602
Hs Code.:

Synonyms:methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

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Chemical Property of methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

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Technology Process of methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

There total 5 articles about methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 160012-71-5
methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-4-hydroxy-4H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

: 160012-73-7
methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

Guidance literature:: With pyridine; methanesulfonyl chloride; at 60 ℃; for 3h;
DOI:10.1016/S0040-4020(01)89394-7

Reference yield:

: 17592-40-4
2-bromo-3,3-diethoxypropene

: 160012-73-7
methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiBr, butyllithium / 1.) THF, hexane, -74 deg C, 20 min; 2.) THF, hexane, ether, -75 deg C, 2 h

2: 68 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

3: 94 percent / tert-butylhypochlorite / methanol; tetrahydrofuran / 1.5 h / -70 °C

4: 67 percent / methanesulfonyl chloride, pyridine / 3 h / 60 °C

With pyridine; n-butyllithium; tert-butylhypochlorite; methanesulfonyl chloride; triethylamine; lithium bromide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)89394-7

Reference yield:

: 121534-84-7
(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-thiocarbamoyl-acetic acid methyl ester

: 160012-73-7
methyl 2-(4-ethoxycarbonyl-5-diethoxymethyl-6H-1,3-thiazin-2-yl)-2-methoxy-2-o-methoxycarbonylbenzamidoethanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

2: 94 percent / tert-butylhypochlorite / methanol; tetrahydrofuran / 1.5 h / -70 °C

3: 67 percent / methanesulfonyl chloride, pyridine / 3 h / 60 °C

With pyridine; tert-butylhypochlorite; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)89394-7