(R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

Base Information

Chemical Name:(R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide
CAS No.:1239670-01-9
Molecular Formula:C₂₂H₂₃F₄N₃O₅S₂
Molecular Weight:549.567
Hs Code.:

Synonyms:(R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

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Chemical Property of (R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

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Technology Process of (R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

There total 2 articles about (R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87310-69-8
N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide

: 1239670-01-9
(R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 40 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

2.2: -45 - -20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With titanium(IV) tetraethanolate; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ml3000269

Reference yield:

: 1239670-39-3
S(R)-2-(tert-butylsulfinylimino)-N-(4-cyano-3-(trifluoromethyl)phenyl) propanamide

: 1239670-01-9
(R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(1,1-dimethylethylsulfonamido)-3-(4-fluorophenyl sulfonyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

1.2: -45 - -20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ml3000269