N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide
CAS No.:858344-75-9
Molecular Formula:C₂₄H₃₂N₂O₄
Molecular Weight:412.529
Hs Code.:

<i>N</i>-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

Synonyms:N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

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Chemical Property of N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

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Technology Process of N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

There total 8 articles about N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 858344-59-9
N-[4-(hydroxy-m-tolyl-methyl)-2-methoxy-5-(3-methoxy-propyl)-6-methyl-pyridin-3-yl]-2,2-dimethyl-propionamide

: 858344-75-9
N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In acetone; at 5 ℃; for 1h;
DOI:10.1021/jm0408621

Reference yield:

: 858344-43-1
3-amino-5-(3-methoxy-propyl)-6-methyl-1H-pyridin-2-one

: 858344-75-9
N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: Ag₂CO₃ / CH₂Cl₂ / 96 h / 20 °C

3.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / 0 °C

3.2: 43 percent / tetrahydrofuran / 3 h / 0 °C

4.1: 95 percent / aq. H₂SO₄; CrO₃ / acetone / 1 h / 5 °C

With chromium(VI) oxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; triethylamine; silver carbonate; In tetrahydrofuran; dichloromethane; acetone; 4.1: Jones oxidation;
DOI:10.1021/jm0408621

Reference yield:

: 847741-05-3
3-acetyl-5-(3-methoxypropyl)-6-methylpyridin-2(1H)-one

: 858344-75-9
N-[2-methoxy-5-(3-methoxy-propyl)-6-methyl-4-(3-methyl-benzoyl)-pyridin-3-yl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: NH₂OH*HCl / ethanol / 2 h / 20 °C

2.1: HCO₂H / 1 h / 100 °C

3.1: aq. HCl / 2 h / Heating

4.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: Ag₂CO₃ / CH₂Cl₂ / 96 h / 20 °C

6.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / 0 °C

6.2: 43 percent / tetrahydrofuran / 3 h / 0 °C

7.1: 95 percent / aq. H₂SO₄; CrO₃ / acetone / 1 h / 5 °C

With chromium(VI) oxide; hydrogenchloride; n-butyllithium; formic acid; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; hydroxylamine hydrochloride; triethylamine; silver carbonate; In tetrahydrofuran; ethanol; dichloromethane; acetone; 2.1: Beckmann rearrangement / 7.1: Jones oxidation;
DOI:10.1021/jm0408621