1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

Base Information

Chemical Name:1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide
CAS No.:1033586-64-9
Molecular Formula:C₂₇H₂₅Cl₂N₃O₄S
Molecular Weight:558.485
Hs Code.:

Synonyms:1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

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Chemical Property of 1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

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Technology Process of 1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

There total 4 articles about 1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1033586-62-7
1-(4-bromo-2-chlorophenyl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

: 373384-18-0
3-(methanesulfonyl)phenylboronic acid

: 1033586-64-9
1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: With water; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; at 80 ℃; for 2.5h;

Reference yield:

: 1033586-61-6
1-(4-bromo-2-chlorophenyl)-2-(2-chlorophenyl)-1H-imidazole-4-carboxylic acid

: 1033586-64-9
1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

2: water; potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2.5 h / 80 °C

With dmap; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; dichloromethane; 2: Suzuki Coupling;

Reference yield:

: 1033586-86-5
1-(4-bromo-2-chlorophenyl)-2-(2-chlorophenyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 1033586-64-9
1-(3-chloro-3'-(methylsulfonyl)biphenyl-4-yl)-2-(2-chlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / methanol / 2 h / 50 °C

2: hydrogenchloride / methanol; water; ethyl acetate

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

4: water; potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2.5 h / 80 °C

With hydrogenchloride; dmap; sodium hydroxide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; 4: Suzuki Coupling;