3-Thiophenemethanamine,5-amino-(9CI)

Base Information

• Chemical Name: 3-Thiophenemethanamine,5-amino-(9CI)
• CAS No.: 197893-34-8
• Molecular Formula: C₅H₈N₂S
• Molecular Weight: 128.198
• Mol file: 197893-34-8.mol

Synonyms:3-Thiophenemethanamine,5-amino-(9CI)

Chemical Property of 3-Thiophenemethanamine,5-amino-(9CI)

Chemical Property:

• Boiling Point: 283.6±25.0 °C(Predicted)
• PKA: 9.46±0.29(Predicted)
• PSA: 80.28000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 2.07050

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Thiophenemethanamine,5-amino-(9CI)

There total 2 articles about 3-Thiophenemethanamine,5-amino-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C-(5-Nitro-thiophen-3-yl)-methylamine (771582-78-6) → 2-amino-4-(aminomethyl)thiophene (197893-34-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; acetic acid; for 24h; under 3102.9 Torr;

DOI:10.1021/jm970493r

Reference yield:

3-cyano-5-nitrothiophene (42137-23-5) → 2-amino-4-(aminomethyl)thiophene (197893-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BH₃, 2.) 6N aq. HCl / 1.) THF, RT, 4 h, 2.) THF, MeOH, overnight

2: 94 percent / H₂ / 10percent Pd/C / ethanol; aq. acetic acid / 24 h / 3102.9 Torr

With hydrogenchloride; borane; hydrogen; palladium on activated charcoal; In ethanol; acetic acid;

DOI:10.1021/jm970493r

Reference yield:

(S)-1-((R)-2-tert-Butoxycarbonylamino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (177583-50-5) + 2-amino-4-(aminomethyl)thiophene (197893-34-8) → ((R)-1-{(S)-2-[(5-Amino-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-dicyclohexyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In various solvent(s); for 5h; Ambient temperature;

DOI:10.1021/jm970493r

upstream raw materials:

C-(5-Nitro-thiophen-3-yl)-methylamine

3-cyano-5-nitrothiophene

Refernces