ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

Base Information

Chemical Name:ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate
CAS No.:1159317-84-6
Molecular Formula:C₂₂H₃₁NO₃
Molecular Weight:357.493
Hs Code.:

Synonyms:ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

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Chemical Property of ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

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Technology Process of ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

There total 1 articles about ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 4524-93-0
Cyclopentanecarboxylic acid chloride

: 1159317-82-4
ethyl 5-(4-ethylphenyl)piperidine-3-carboxylate

: 1159317-84-6
ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

Guidance literature:: With piperidine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 87.0%

: 1159317-84-6
ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

: 1048766-73-9
1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid

Guidance literature:: ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=1;

Reference yield:

: 1159317-84-6
ethyl 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylate

: cis-1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

1.2: pH 1

2.1: Kromasil 100 / trifluoroacetic acid; acetonitrile / 23 °C / Resolution of racemate

3.1: triethylamine; diphenyl phosphoryl azide; di-tert-butyl dicarbonate / toluene; tert-butyl alcohol / 65 - 95 °C / Inert atmosphere

3.2: Inert atmosphere

With di-tert-butyl dicarbonate; diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; toluene; acetonitrile; trifluoroacetic acid; tert-butyl alcohol;