3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Base Information

Chemical Name:3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde
CAS No.:81477-10-3
Molecular Formula:C₁₄H₁₇ClO₃
Molecular Weight:268.74
Hs Code.:

Synonyms:3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Suppliers and Price of 3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

There total 11 articles about 3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 81477-09-0
3-chloro-4,6-dimethoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

: 81477-10-3
3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Guidance literature:: With pyridine; (CH₃)SiI; In chloroform; at 60 ℃; for 96h;
DOI:10.1021/jo00133a027

Reference yield:

: 504-15-4
orcinol

: 81477-10-3
3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Guidance literature:: Multi-step reaction with 11 steps

1: K₂CO₃ / acetone / Heating

2: 1.) n-BuLi / 1.) THF, RT, overnight, 2.) xylene, reflux, 4 h

3: 75 percent / 1.) KMnO₄, (n-Bu)4NBr 2.) 6percent aq. NaOH / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) RT, 18 h

4: 98 percent / p-TsOH / 5 h / Ambient temperature

5: 92 percent / N-bromosuccinimide / dimethylformamide / 18 h / Ambient temperature

6: 92 percent / Cl₂, pyridine / CHCl₃ / 96 h / 0 °C

7: 99.5 percent / conc. HCl / methanol / 4 h / Ambient temperature

8: 99 percent / NaIO₄, H₂O / ethyl acetate / Ambient temperature

9: 1.) n-BuLi / 1.) THF, RT, 30 min, 2.) 50 deg C, 1 h

10: 1.) Mg, 1,2-dibromoethane / 1.) Et₂O, reflux, 4 h, 2.) THF, 0 deg C, 20 min

11: 31 percent / (CH₃)SiI, pyridine / CHCl₃ / 96 h / 60 °C

With pyridine; hydrogenchloride; sodium hydroxide; potassium permanganate; sodium periodate; N-Bromosuccinimide; n-butyllithium; (CH₃)SiI; tetrabutylammomium bromide; water; chlorine; potassium carbonate; toluene-4-sulfonic acid; magnesium; ethylene dibromide; In methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00133a027

Reference yield:

: 4179-19-5
1,3-dimethoxy-5-methylbenzene

: 81477-10-3
3-chloro-4-hydroxy-6-methoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) n-BuLi / 1.) THF, RT, overnight, 2.) xylene, reflux, 4 h

2: 75 percent / 1.) KMnO₄, (n-Bu)4NBr 2.) 6percent aq. NaOH / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) RT, 18 h

3: 98 percent / p-TsOH / 5 h / Ambient temperature

4: 92 percent / N-bromosuccinimide / dimethylformamide / 18 h / Ambient temperature

5: 92 percent / Cl₂, pyridine / CHCl₃ / 96 h / 0 °C

6: 99.5 percent / conc. HCl / methanol / 4 h / Ambient temperature

7: 99 percent / NaIO₄, H₂O / ethyl acetate / Ambient temperature

8: 1.) n-BuLi / 1.) THF, RT, 30 min, 2.) 50 deg C, 1 h

9: 1.) Mg, 1,2-dibromoethane / 1.) Et₂O, reflux, 4 h, 2.) THF, 0 deg C, 20 min

10: 31 percent / (CH₃)SiI, pyridine / CHCl₃ / 96 h / 60 °C

With pyridine; hydrogenchloride; sodium hydroxide; potassium permanganate; sodium periodate; N-Bromosuccinimide; n-butyllithium; (CH₃)SiI; tetrabutylammomium bromide; water; chlorine; toluene-4-sulfonic acid; magnesium; ethylene dibromide; In methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00133a027