CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID

Base Information

• Chemical Name: CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID
• CAS No.: 197794-44-8
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 197794-44-8.mol

Synonyms:CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID;Cycloheptanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]- (9CI)

Chemical Property of CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID

Chemical Property:

• Boiling Point: 489.8±34.0 °C(Predicted)
• PKA: 4.04±0.20(Predicted)
• PSA: 79.12000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 3.29480

Purity/Quality:

97% ^*data from raw suppliers

CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID

There total 3 articles about CBZ-1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-aminocycloheptane-1-carboxylic acid (6949-77-5) + benzyl chloroformate (501-53-1,94274-21-2) → 1-Benzyloxycarbonylamino-cycloheptanecarboxylic acid (197794-44-8)

Guidance literature:

With hydrogenchloride; zinc; In water; acetonitrile;

Reference yield:

1,3-diaza-spiro[4.6]undecane-2,4-dione (707-16-4) → 1-Benzyloxycarbonylamino-cycloheptanecarboxylic acid (197794-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

With sodium hydroxide;

DOI:10.1039/a701473b

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 1-aminocycloheptane-1-carboxylic acid (6949-77-5) → 1-Benzyloxycarbonylamino-cycloheptanecarboxylic acid (197794-44-8)

Guidance literature:

DOI:10.1039/a701473b

upstream raw materials:

N-(Benzyloxycarbonyloxy)succinimide

1-aminocycloheptane-1-carboxylic acid

benzyl chloroformate

1,3-diaza-spiro[4.6]undecane-2,4-dione

Refernces

• 1、 Babu, Vommina V. Suresh,Ananda, Kuppanna. "Zinc promoted rapid and efficient synthesis of Fmoc- and Z-α,α-dialkylamino acids under neutral conditions". . p. 70 - 74. Retrieved 2007/10/03.