Technology Process of (2S,3R,5S)-2-Acetoxy-3-iodo-5-pivaloyloxymethyl tetrahydrofuran
There total 1 articles about (2S,3R,5S)-2-Acetoxy-3-iodo-5-pivaloyloxymethyl tetrahydrofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / 4 h / 50 °C
2: DIBAL-H / tetrahydrofuran / 2 h / -78 °C
3: thionyl chloride / CH2Cl2 / 2 h / 23 °C
4: potassium t-butoxide / tetrahydrofuran / 1 h / -78 °C
5: N-iodosuccinimide / 1 h / -20 °C
With
pyridine; N-iodo-succinimide; thionyl chloride; potassium tert-butylate; diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4039(92)89018-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: SnCl4 / 1,2-dichloro-ethane / -20 deg C -> 23 deg C
2: H2 / 10 percent Pd/C / ethanol / 3 h
3: CH3ONa / methanol / 5 h / 23 °C
With
hydrogen; sodium methylate; tin(IV) chloride;
palladium on activated charcoal;
In
methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(92)89018-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1: SnCl4 / 1,2-dichloro-ethane / -20 deg C -> 23 deg C
2: H2 / 10 percent Pd/C / ethanol / 3 h
With
hydrogen; tin(IV) chloride;
palladium on activated charcoal;
In
ethanol; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(92)89018-8
