Technology Process of methyl 3-(2-(1-phenylbut-3-enyl)phenyl)propiolate
There total 5 articles about methyl 3-(2-(1-phenylbut-3-enyl)phenyl)propiolate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(2,2-dibromovinyl)-2-(1-phenylbut-3-enyl)benzene;
With
methyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
methyl chloroformate;
In
tetrahydrofuran; hexane;
at -78 ℃;
DOI:10.1002/anie.200905478
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran / 1.75 h / -78 - -20 °C
1.2: 1.17 h / -78 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere
3.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
4.1: triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: methyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
5.2: -78 °C
With
lithium aluminium tetrahydride; n-butyllithium; methyllithium; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/anie.200905478
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
2.1: triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: methyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: -78 °C
With
methyllithium; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/anie.200905478
