4-Pyridinol,2,6-difluoro-(9CI)

Base Information

• Chemical Name: 4-Pyridinol,2,6-difluoro-(9CI)
• CAS No.: 197717-50-3
• Molecular Formula: C₅H₃F₂NO
• Molecular Weight: 131.082
• Mol file: 197717-50-3.mol

Synonyms:4-Pyridinol,2,6-difluoro-(9CI)

Chemical Property of 4-Pyridinol,2,6-difluoro-(9CI)

Chemical Property:

• Boiling Point: 378.7±37.0 °C(Predicted)
• PKA: 6.22±0.23(Predicted)
• PSA: 33.12000
• Density: 1.464±0.06 g/cm3(Predicted)
• LogP: 1.06540

Purity/Quality:

99% ^*data from raw suppliers

2,6-Difluoro-4-pyridinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinol,2,6-difluoro-(9CI)

There total 4 articles about 4-Pyridinol,2,6-difluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,6-difluoro pyridine (1513-65-1) → 2,6-difluoro-3-hydroxypyridine (209328-85-8) + 2,6-difluoropyridin-4-ol (197717-50-3)

Guidance literature:

2,6-difluoro pyridine; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 80 ℃; for 16h; Sealed tube; Inert atmosphere; Schlenk technique;

With Oxone; water; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

Reference yield: 73.0%

2,6-difluoro pyridine (1513-65-1) → 2,6-difluoropyridin-4-ol (197717-50-3)

Guidance literature:

2,6-difluoro pyridine; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 80 ℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;

With Oxone; In tetrahydrofuran; water; for 0.166667h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.organomet.9b00816

Reference yield:

2,6-difluoro-4-methoxypyridine (1184172-35-7) → 2,6-difluoropyridin-4-ol (197717-50-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 60 ℃;

upstream raw materials:

2,4,6-trifluoropyridine

2,6-difluoro-4-methoxypyridine

2,6-difluoro pyridine