3-Oxa-7-azabicyclo[4.1.0]heptane, 7-acetyl-4-methoxy-, [1R-(1alpha,4alpha,6alpha)]- (9CI)

Base Information

Chemical Name:3-Oxa-7-azabicyclo[4.1.0]heptane, 7-acetyl-4-methoxy-, [1R-(1alpha,4alpha,6alpha)]- (9CI)
CAS No.:197715-54-1
Molecular Formula:C₈H₁₃NO₃
Molecular Weight:171.196
Hs Code.:
Mol file:197715-54-1.mol

Synonyms:3-Oxa-7-azabicyclo[4.1.0]heptane,7-acetyl-4-methoxy-, [1R-(1a,4a,6a)]- (9CI)

Suppliers and Price of 3-Oxa-7-azabicyclo[4.1.0]heptane, 7-acetyl-4-methoxy-, [1R-(1alpha,4alpha,6alpha)]- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Oxa-7-azabicyclo[4.1.0]heptane, 7-acetyl-4-methoxy-, [1R-(1alpha,4alpha,6alpha)]- (9CI)

Chemical Property:

PSA：38.54000
LogP:-0.08360

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxa-7-azabicyclo[4.1.0]heptane, 7-acetyl-4-methoxy-, [1R-(1alpha,4alpha,6alpha)]- (9CI)

There total 4 articles about 3-Oxa-7-azabicyclo[4.1.0]heptane, 7-acetyl-4-methoxy-, [1R-(1alpha,4alpha,6alpha)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108-24-7
acetic anhydride

: 197715-53-0
(1R,4S,6R)-4-methoxy-3-oxa-7-azabicyclo[4.1.0]heptane

: 197715-54-1
(1R,4S,6R)-4-methoxy-7-acetyl-3-oxa-7-azabicyclo[4.1.0]heptane

Guidance literature:: With potassium carbonate; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00921-6

Reference yield:

: 6160-56-1
methyl 2-deoxy-α-D-erythro-pentopyranoside

: 197715-54-1
(1R,4S,6R)-4-methoxy-7-acetyl-3-oxa-7-azabicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 2 steps

2: 96 percent / K₂CO₃ / CH₂Cl₂ / 3 h / Ambient temperature

With potassium carbonate; In dichloromethane;
DOI:10.1016/S0040-4020(97)00921-6

Reference yield:

: (3aR,6S,7aS)-6-Methoxy-tetrahydro-[1,3,2]dioxathiolo[4,5-c]pyran 2-oxide

: 197715-54-1
(1R,4S,6R)-4-methoxy-7-acetyl-3-oxa-7-azabicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaIO₄, RuCl₃ / CH₂Cl₂; acetonitrile; H₂O / 1 h / Ambient temperature

2: 1.) LiN₃, 2.) LiAlH₄ / 1.) THF, reflux, 12 h, 2.) THF, reflux, 8 h

3: 96 percent / K₂CO₃ / CH₂Cl₂ / 3 h / Ambient temperature

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; lithium azide; potassium carbonate; In dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(97)00921-6