(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Base Information

Chemical Name:(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene
CAS No.:254442-46-1
Molecular Formula:C₄₁H₅₈O₇SSi₂
Molecular Weight:751.144
Hs Code.:

(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Synonyms:(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Suppliers and Price of (4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

There total 7 articles about (4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 189347-94-2
tert-Butyl-[(2S,3R)-2-methyl-3-(toluene-4-sulfonyl)-oxiranylmethoxy]-diphenyl-silane

: 254442-44-9
trifluoromethanesulfonic acid [(4aS,6R,7S,9aR)-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocyclohepten-6-yl]methyl ester

: 254442-46-1
(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; at -100 ℃;
DOI:10.1016/S0040-4039(99)01665-2

Reference yield:

: 196795-17-2
(4aS,6R,9aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-hexahydro-1,5-dioxa-benzocyclohepten-7-one

: 254442-46-1
(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / tetrahydrofuran; toluene / 0.5 h / 20 °C

2.1: 70 percent / m-chloroperbenzoic acid; phosphate buffer / CH₂Cl₂; H₂O / 6 h / 20 °C / pH 7

3.1: 99 percent / lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C

4.1: 100 percent / Bu₄NF / tetrahydrofuran / 1.5 h / 20 °C

5.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

5.2: 88 percent / CH₂Cl₂ / 0.5 h

6.1: 91 percent / HMPA; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -100 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; phosphate buffer; tetrabutyl ammonium fluoride; lithium triethylborohydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2003.09.016

Reference yield:

: 254442-42-7
(4aS,6R,7S,9aR)-6-hydroxymethyl-7-methyloctahydro-1,5-dioxabenzocyclohepten-7-ol

: 254442-46-1
(4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 88 percent / CH₂Cl₂ / 0.5 h

2.1: 91 percent / HMPA; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -100 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2003.09.016