(1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene

Base Information

• Chemical Name: (1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene
• CAS No.: 104173-03-7
• Molecular Formula: C₂₉H₅₁NO₃SSi₂
• Molecular Weight: 549.966
• Mol file: 104173-03-7.mol

Synonyms:(1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene

Chemical Property of (1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene

There total 11 articles about (1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C32H61NO4SSi3 (104173-02-6,104196-36-3) → C29H51NO3SSi2 (104173-00-4,104173-03-7,118892-47-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃;

Reference yield: 91.0%

C32H61NO4SSi3 (104173-02-6,104196-36-3) → C29H51NO3SSi2 (104173-00-4,104173-03-7,118892-47-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃;

Reference yield: 91.0%

(2S,3aS,4S,5R,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-((R)-N-methyl-S-phenylsulfonimidoyl)octahydropentalen-2-ol → (1S,2R,3aS,6aS,E)-5-(((R)-N-methyl-S-phenylsulfonimidoyl)methylene)-2-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalene (104173-03-7)

Guidance literature:

(2S,3aS,4S,5R,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-(((tert-butyldimethylsilyl)oxy)methyl)-2-((R)-N-methyl-S-phenylsulfonimidoyl)octahydropentalen-2-ol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h;

With chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 20 ℃; for 4h;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1002/chem.201901163

upstream raw materials:

C₃₂H₆₁NO₄SSi₃

C₃₂H₆₁NO₄SSi₃

(+)-(S)-(N-methylphenylsulfonimidoyl)methyllithium

(3aS,4S,5R,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-(((tert-butyldimethylsilyl)oxy)methyl)hexahydropentalen-2(1H)-one

Downstream raw materials:

(((1S,2R,3aS,6aS,Z)-5-benzylidene-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalen-2-yl)oxy)(tert-butyl)dimethylsilane

(((1S,2R,3aS,6aS,E)-5-benzylidene-1-(((tert-butyldimethylsilyl)oxy)methyl)octahydropentalen-2-yl)oxy)(tert-butyl)dimethylsilane

C₂₈H₄₇BrMgO₂Si₂

C₂₈H₄₇BrMgO₂Si₂