5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

Base Information

Chemical Name:5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid
CAS No.:1403680-13-6
Molecular Formula:C₁₇H₁₅ClN₄O₂
Molecular Weight:342.785
Hs Code.:

Synonyms:5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

There total 5 articles about 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403679-99-1
ethyl 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylate

: 1403680-13-6
5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 20h; Reflux;
DOI:10.1016/j.bmc.2014.06.025

Reference yield:

: 951784-50-2
ethyl 4-(2-aminopyrimidin-4-yl)-2-cyano-4-oxobutanoate

: 1403680-13-6
5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrogen bromide / dichloromethane / 0 - 20 °C

2: lithium chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene; water / 5 h / 100 °C / Inert atmosphere

3: potassium hydroxide / ethanol / 20 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; hydrogen bromide; sodium carbonate; acetic acid; lithium chloride; potassium hydroxide; In ethanol; dichloromethane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.06.025

Reference yield:

: ethyl 5-(2-aminopyrimidin-4-yl)-2-bromo-1H-pyrrole-3-carboxylate

: 1403680-13-6
5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene; water / 5 h / 100 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 20 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; lithium chloride; potassium hydroxide; In ethanol; water; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.06.025