ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate

Base Information

• Chemical Name: ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate
• CAS No.: 1044549-00-9
• Molecular Formula: C₂₀H₁₆ClN₃O₄
• Molecular Weight: 397.818
• Mol file: 1044549-00-9.mol

Synonyms:ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate

Chemical Property of ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate

There total 3 articles about ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,3-dihydrophthalazine-1,4-dione (1445-69-8) + 2-chloro-benzaldehyde (89-98-5) + ethyl 2-cyanoacetate (105-56-6) → ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate (1044549-00-9)

Guidance literature:

at 45 ℃; for 0.0833333h; Ionic liquid; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.08.111

Reference yield: 88.0%

phthalic anhydride (85-44-9) + 2-chloro-benzaldehyde (89-98-5) + ethyl 2-cyanoacetate (105-56-6) → ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate (1044549-00-9)

Guidance literature:

phthalic anhydride; With hydrazine hydrate; L-proline; lithium chloride; In ethanol; water; at 80 ℃; for 4h;

2-chloro-benzaldehyde; ethyl 2-cyanoacetate; In ethanol; water; at 80 ℃; enantioselective reaction;

DOI:10.1080/00397911.2016.1192650

Reference yield: 88.0%

phthalimide (136918-14-4,85-41-6) + 2-chloro-benzaldehyde (89-98-5) + ethyl 2-cyanoacetate (105-56-6) → ethyl 3-amino-1-(2-chlorophenyl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1, 2-b]phthalazine-2-carboxylate (1044549-00-9)

Guidance literature:

phthalimide; With hydrazine hydrate; L-proline; lithium chloride; In ethanol; water; at 80 ℃; for 4h;

2-chloro-benzaldehyde; ethyl 2-cyanoacetate; In ethanol; water; at 80 ℃; enantioselective reaction;

DOI:10.1080/00397911.2016.1192650

upstream raw materials:

2,3-dihydrophthalazine-1,4-dione

2-chloro-benzaldehyde

ethyl 2-cyanoacetate

phthalimide