Technology Process of 2-(3-(4-methoxybenzyloxy)propyl)-3-((Z)-dec-1-enyl)-4,6-dimethylpyridine
There total 8 articles about 2-(3-(4-methoxybenzyloxy)propyl)-3-((Z)-dec-1-enyl)-4,6-dimethylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-(4-methoxybenzyloxy)propyl)-3-bromo-4,6-dimethylpyridine;
With
palladium diacetate; sodium carbonate; triphenylphosphine;
In
water; toluene;
for 0.5h;
Inert atmosphere;
diisopropyl (Z)-1-decenylboronate;
In
ethanol; water; toluene;
for 5h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.bmcl.2012.05.127
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / 2 h / 120 °C
2.1: bromine; sodium hydroxide / water / 2 h / -5 - 70 °C
3.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere
4.1: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 72 h
5.1: 1-nitrobutane; copper(ll) bromide / Bromoform / 2 h / 20 °C
6.1: palladium diacetate; sodium carbonate; triphenylphosphine / water; toluene / 0.5 h / Inert atmosphere
6.2: 5 h / Inert atmosphere; Reflux
With
piperidine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1-nitrobutane; sulfuric acid; hydrogen; bromine; palladium diacetate; sodium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; copper(ll) bromide;
In
tetrahydrofuran; ethanol; Bromoform; water; toluene;
DOI:10.1016/j.bmcl.2012.05.127
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: phosphorus pentoxide; tetrabutylammomium bromide / toluene / Reflux
2.1: sulfuric acid / 2 h / 120 °C
3.1: bromine; sodium hydroxide / water / 2 h / -5 - 70 °C
4.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere
5.1: platinum(IV) oxide; hydrogen; triethylamine / ethanol / 72 h
6.1: 1-nitrobutane; copper(ll) bromide / Bromoform / 2 h / 20 °C
7.1: palladium diacetate; sodium carbonate; triphenylphosphine / water; toluene / 0.5 h / Inert atmosphere
7.2: 5 h / Inert atmosphere; Reflux
With
piperidine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1-nitrobutane; phosphorus pentoxide; sulfuric acid; tetrabutylammomium bromide; hydrogen; bromine; palladium diacetate; sodium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; copper(ll) bromide;
In
tetrahydrofuran; ethanol; Bromoform; water; toluene;
DOI:10.1016/j.bmcl.2012.05.127
