2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on

Base Information

• Chemical Name: 2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on
• CAS No.: 127817-99-6
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.154
• Mol file: 127817-99-6.mol

Synonyms:2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on

Chemical Property of 2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on

There total 1 articles about 2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.3%

2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on-ethylenacetal (127817-98-5) → ethylene glycol diformate (629-15-2) + 2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on (127817-99-6)

Guidance literature:

With formic acid; for 6h; Ambient temperature;

DOI:10.1002/ardp.19903230202

Reference yield:

2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on (127817-99-6) → 2,3,8,8a-Tetrahydro-8-(4-nitrobenzyliden)-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on (130089-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.2 percent / NEt₃ / tetrahydrofuran / 66 h / Heating

2: 8.9 percent / Bu₄NF / tetrahydrofuran / 1.) 3 h, -78 deg C, 2.) 1 h, -30 to -40 deg C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;

DOI:10.1002/ardp.19903230808

Reference yield:

2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on (127817-99-6) → N-(Perhydro-7-phenyl-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7-yl)-piperidin (130089-58-6,130144-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 44.4 percent / HCl / H₂O / 18 h

2: 3.5 percent / diethyl ether / 40 h

With hydrogenchloride; In diethyl ether; water;

DOI:10.1002/ardp.19903230808

upstream raw materials:

2,3,8,8a-Tetrahydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on-ethylenacetal

Downstream raw materials:

Methyl-2,3,4a,4b,5,8a,9,10a-octahydro-8a-hydroxy-5-phenyl-1,4,8,10-tetraoxaphenanthren-7-carboxylat

N-(Perhydro-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7-yl)-N'-phenylharnstoff

2,3,8,8a-Tetrahydro-8-(4-nitrobenzyliden)-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7(6H)-on

N-(Perhydro-7-phenyl-cis-4aH-pyrano<2,3-b>-<1,4>dioxin-7-yl)-piperidin