1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

Base Information

Chemical Name:1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine
CAS No.:1630041-46-1
Molecular Formula:C₃₅H₃₇F₆N₃O₂
Molecular Weight:645.688
Hs Code.:

Synonyms:1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

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Chemical Property of 1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

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Technology Process of 1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

There total 4 articles about 1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1458-63-5
N-(3-chloropropyl)-piperidine

: 1630041-31-4
C₂₇H₂₂F₆N₂O₂

: 1630041-46-1
1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

Guidance literature:: C₂₇H₂₂F₆N₂O₂; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

N-(3-chloropropyl)-piperidine; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.2174/1570180811666140116214111

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 1630041-46-1
1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 3 h / Reflux

2.1: potassium carbonate / acetone / 5 h / 40 °C

3.1: ammonium acetate; acetic acid

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 2 h / 60 °C

With ammonium acetate; sodium hydride; potassium carbonate; acetic acid; In N,N-dimethyl-formamide; acetone;
DOI:10.2174/1570180811666140116214111

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 1630041-46-1
1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 5 h / 40 °C

2.1: ammonium acetate; acetic acid

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 2 h / 60 °C

With ammonium acetate; sodium hydride; potassium carbonate; acetic acid; In N,N-dimethyl-formamide; acetone;
DOI:10.2174/1570180811666140116214111