2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester

Base Information

• Chemical Name: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester
• CAS No.: 241823-98-3
• Molecular Formula: C₄₂H₃₅NO₆
• Molecular Weight: 649.743
• Mol file: 241823-98-3.mol

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester

Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester

There total 1 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

9-bromo-9-phenyl-9H-fluorene (55135-66-5) + Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester (144120-54-7) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester (241823-98-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 14h;

Reference yield: 80.0%

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester (241823-98-3) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester (241824-00-0)

Guidance literature:

With N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾;

Reference yield:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester (241823-98-3) → 4-amino-4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-butyric acid 9-phenyl-9H-fluoren-9-yl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / PhNHMe / Pd(PPh₃)4

2: 75 percent / DIPEA; tetramethylfluoroformamidinium hexafluorophosphate

3: morpholine / dimethylformamide / 0.25 h

With morpholine; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 1: Deallylation / 2: Acylation / 3: Cyclization;

upstream raw materials:

9-bromo-9-phenyl-9H-fluorene

Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester

Downstream raw materials:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-(9-phenyl-9H-fluoren-9-yl) ester

2-(2-tert-butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-(9-phenyl-9H-fluoren-9-yl) ester

4-(2-tert-butoxy-1-tert-butoxycarbonyl-ethylcarbamoyl)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 9-phenyl-9H-fluoren-9-yl ester