({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

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Chemical Name:({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester
CAS No.:206861-73-6
Molecular Formula:C₃₁H₃₂N₃O₈P
Molecular Weight:605.584
Hs Code.:

Synonyms:({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

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Chemical Property of ({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

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Technology Process of ({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

There total 4 articles about ({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 20924-05-4
thymidyl acetic acid

: 206861-69-0
{[2-(9-Phenyl-9H-xanthen-9-yloxy)-ethylamino]-methyl}-phosphonic acid dimethyl ester

: 206861-73-6
({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

Guidance literature:: With triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 1.) 0 deg C, 1 h, 2.) room temperature, 20 h;
DOI:10.1016/S0968-0896(97)10041-4

Reference yield:

: 42506-03-6
pixyl chloride

: 206861-73-6
({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine, 2.) hydrazine monohydrate / 1.) room temperature, 4 h, 2.) CH₂Cl₂, methanol, room temperature, 16 h

2: 71 percent / ethyldiisopropylamine / 2 h / 0 °C

3: 70 percent / triethylamine, dicyclohexylcarbodiimide, 3-hydroxy-1,2,3-benzotriazin-4-one / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temperature, 20 h

With pyridine; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)10041-4

Reference yield:

: (9-Phenyl-9H-xanthen-9-yloxy)-acetaldehyde

: 206861-73-6
({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 70 percent / triethylamine, dicyclohexylcarbodiimide, 3-hydroxy-1,2,3-benzotriazin-4-one / dimethylformamide; CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temperature, 20 h

With triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)10041-4