N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

Base Information

Chemical Name:N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine
CAS No.:241147-37-5
Molecular Formula:C₃₀H₄₄N₂O₈
Molecular Weight:560.688
Hs Code.:

N<sup>1</sup>,N<sup>8</sup>-bis(benzyloxy)-N<sup>1</sup>,N<sup>8</sup>-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

Synonyms:N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

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Technology Process of N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

There total 1 articles about N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79722-21-7
tert-butyl N-(benzyloxy)carbamate

: 112-26-5,27252-69-3
1,2-bis(2-chloroethoxy)ethane

: 241147-37-5
N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

Guidance literature:: With sodium hydride; Yield given; Multistep reaction; 1.) DMF, RT, 40 min, 2.) DMF, 53 deg C, 21 h;
DOI:10.1021/jm980611q

Reference yield: 84.0%

: 241147-37-5
N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

: 98902-91-1
N¹,N⁸-bis(benzyloxy)-3,6-dioxa-1,8-octanediamine

Guidance literature:: With hydrogenchloride; In methanol; for 20h; Ambient temperature;
DOI:10.1021/jm980611q

Reference yield:

: 241147-37-5
N¹,N⁸-bis(benzyloxy)-N¹,N⁸-bis(tert-butoxycarbonyl)-3,6-dioxa-1,8-octanediamine

: C₂₀H₂₄N₂O₈

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / conc. HCl / methanol / 20 h / Ambient temperature

2: 89 percent / DIEA / CH₂Cl₂ / 4 h / Ambient temperature

3: 91 percent / NaOMe / methanol / 1 h / 0 °C

4: 81 percent / H₂ / 10 percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

With hydrogenchloride; hydrogen; sodium methylate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm980611q