1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

Base Information

Chemical Name:1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester
CAS No.:349609-07-0
Molecular Formula:C₃₈H₃₇N₃O₇
Molecular Weight:647.728
Hs Code.:

1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

Synonyms:1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

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Chemical Property of 1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

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Technology Process of 1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

There total 11 articles about 1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62717-78-6,141303-38-0
2-(2-methoxyphenyl)oxirane

: 349609-07-0
1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: aq. NaN₃ / acetone / 3 h / Heating

2.1: NaH / tetrahydrofuran; various solvent(s) / 0.25 h / 20 °C

2.2: 13.18 g / KI / tetrahydrofuran; various solvent(s) / 2 h

3.1: 87 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

4.1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

5.1: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

6.1: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

7.1: 10.0 g / DMAP; pyridine / CH₂Cl₂; dimethylformamide; hexane / 0.75 h / 0 °C

8.1: H₂ / PtO₂ / tetrahydrofuran; ethanol / 16 h / 20 °C / 4137.18 Torr

9.1: aq. HCl / dioxane / 0.25 h / 90 °C

10.1: 5.22 g / pyridine / CH₂Cl₂ / 18 h / 4 °C

With pyridine; hydrogenchloride; dmap; lithium hydroxide; sodium azide; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja0174027

Reference yield:

: 108343-89-1
1-[1-amino-2-(phenylmethoxy)ethyl]-2-methoxy-benzene

: 349609-07-0
1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

2: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

3: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

4: 10.0 g / DMAP; pyridine / CH₂Cl₂; dimethylformamide; hexane / 0.75 h / 0 °C

5: H₂ / PtO₂ / tetrahydrofuran; ethanol / 16 h / 20 °C / 4137.18 Torr

6: aq. HCl / dioxane / 0.25 h / 90 °C

7: 5.22 g / pyridine / CH₂Cl₂ / 18 h / 4 °C

With pyridine; hydrogenchloride; dmap; lithium hydroxide; hydrogen; potassium carbonate; potassium nitrate; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja0174027

Reference yield:

: 2-azido-2-(2-methoxy-phenyl)-ethanol

: 349609-07-0
1,2-dihydro-8-methoxy-2-[((9H-fluoren-9-yl-methoxycarbonyl)methylamino)acetyl]-1-[(phenylmethoxy)methyl]-isoquinolin-7-yl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaH / tetrahydrofuran; various solvent(s) / 0.25 h / 20 °C

1.2: 13.18 g / KI / tetrahydrofuran; various solvent(s) / 2 h

2.1: 87 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

3.1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

4.1: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

5.1: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

6.1: 10.0 g / DMAP; pyridine / CH₂Cl₂; dimethylformamide; hexane / 0.75 h / 0 °C

7.1: H₂ / PtO₂ / tetrahydrofuran; ethanol / 16 h / 20 °C / 4137.18 Torr

8.1: aq. HCl / dioxane / 0.25 h / 90 °C

9.1: 5.22 g / pyridine / CH₂Cl₂ / 18 h / 4 °C

With pyridine; hydrogenchloride; dmap; lithium hydroxide; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja0174027