(+/-)-(1R,2R,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Base Information

Chemical Name:(+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane
CAS No.:134031-42-8
Molecular Formula:C₂₂H₂₈ClNO₂
Molecular Weight:373.923
Hs Code.:

Synonyms:(+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Suppliers and Price of (+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

There total 11 articles about (+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147806-34-6
N-(2-{1-[(1R,3R,5R)-3-((E)-1-Hydroxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hex-1-yl]-vinyl}-phenyl)-2,2-dimethyl-propionamide

: 134031-42-8
(+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: With methanesulfonyl chloride; lithium chloride; In N,N-dimethyl-formamide; at -23 - 23 ℃; Yield given;
DOI:10.1021/ja00013a068

Reference yield:

: 930-30-3
cyclopent-2-enone

: 134031-42-8
(+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) t-BuLi, 2.) 2-thienylCuCNLi, 3.) Me₃SiCl

2: 91 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: 1.) 1,1,3,3-tetramethyl-1,3-diphenyl-disilazane, n-BuLi, 3.) Pd(PPh₃)4

4: 1.) MeLi, 2.) t-BuLi

5: t-BuOOH, Triton B / tetrahydrofuran / 2 h / -23 °C

6: 56 percent / tetrahydrofuran / 3 h / Ambient temperature

7: 97 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

8: diisopropylethylamine / CH₂Cl₂ / 0.75 h

9: LiCl / dimethylformamide / 2 h / Ambient temperature

With tert.-butylhydroperoxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; chloro-trimethyl-silane; 1,1,3,3-tetramethyl-1,3-diphenyldisilazane; tetrabutyl ammonium fluoride; methyllithium; tert.-butyl lithium; N-benzyl-trimethylammonium hydroxide; thien-2-yl(cyano)copper lithium; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 134031-36-0
(E)-4-<1-(((triisopropylsilyl)oxy)methyl)-1-propenyl>-1-<(N-methoxy-N-methylamino)carbonyl>cyclopentene

: 134031-42-8
(+/-)-(1R*,2R*,4R*)-4-<1-(chloromethyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)phenyl)ethenyl>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) MeLi, 2.) t-BuLi

2: t-BuOOH, Triton B / tetrahydrofuran / 2 h / -23 °C

3: 56 percent / tetrahydrofuran / 3 h / Ambient temperature

4: 97 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

5: diisopropylethylamine / CH₂Cl₂ / 0.75 h

6: LiCl / dimethylformamide / 2 h / Ambient temperature

With tert.-butylhydroperoxide; tetrabutyl ammonium fluoride; methyllithium; tert.-butyl lithium; N-benzyl-trimethylammonium hydroxide; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;