(Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

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Chemical Name:(Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one
CAS No.:1380295-30-6
Molecular Formula:C₂₆H₂₀ClN₃O₂
Molecular Weight:441.917
Hs Code.:

Synonyms:(Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

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Chemical Property of (Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

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Technology Process of (Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

There total 3 articles about (Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1380295-07-7
5-chloro-1-(4-methoxyphenyl)-3-((2-(p-tolylethynyl)phenyl)amino)pyrazin-2(1H)-one

: 1380295-30-6
(Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

Guidance literature:: With silver trifluoromethanesulfonate; trifluoroacetic acid; In dichloromethane; at 60 ℃; for 0.583333h; regioselective reaction; Inert atmosphere; Microwave irradiation;
DOI:10.1002/adsc.201100881

Reference yield:

: 615-43-0
2-iodophenylamine

: 1380295-30-6
(Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: Reflux

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dimethyl sulfoxide / 0.5 h / 45 °C / Inert atmosphere

3.1: silver trifluoromethanesulfonate; trifluoroacetic acid / dichloromethane / 0.58 h / 60 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver trifluoromethanesulfonate; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2.1: Sonogashira cross-coupling;
DOI:10.1002/adsc.201100881

Reference yield:

: 1380294-86-9
5-chloro-3-((2-iodophenyl)amino)-1-(4-methoxyphenyl)pyrazin-2(1H)-one

: 766-97-2
4-n-methylphenylacetylene

: 1380295-30-6
(Z)-4-chloro-2-(4-methoxyphenyl)-6-(4-methylbenzylidene)-2,6-dihydro-1H-pyrazino[2,1-b]quinazolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dimethyl sulfoxide / 0.5 h / 45 °C / Inert atmosphere

2: silver trifluoromethanesulfonate; trifluoroacetic acid / dichloromethane / 0.58 h / 60 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver trifluoromethanesulfonate; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; 1: Sonogashira cross-coupling;
DOI:10.1002/adsc.201100881