N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

Base Information

Chemical Name:N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide
CAS No.:1253889-46-1
Molecular Formula:C₂₃H₁₆F₆N₂O₃
Molecular Weight:482.382
Hs Code.:

N<sup>(1)</sup>-(3,5-bis(trifluoromethyl)phenyl)-N<sup>(2)</sup>-(3-(hydroxymethyl)phenyl)phthalamide

Synonyms:N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

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Technology Process of N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

There total 4 articles about N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1253889-39-2
3-(3,5-bis(trifluoromethyl)phenylimino)isobenzofuran-1(3H)-one

: 1877-77-6
3-aminobenzenemethanol

: 1253889-46-1
N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201002958

Reference yield:

: 85-44-9
phthalic anhydride

: 1253889-46-1
N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

Guidance literature:: Multi-step reaction with 3 steps

1: chloroform / 3 h / Inert atmosphere; Reflux

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; chloroform;
DOI:10.1002/chem.201102018

Reference yield:

: 24063-31-8
2-(3,5-bis(trifluoromethyl)phenylcarbamoyl)benzoic acid

: 1253889-46-1
N⁽¹⁾-(3,5-bis(trifluoromethyl)phenyl)-N⁽²⁾-(3-(hydroxymethyl)phenyl)phthalamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran;
DOI:10.1002/chem.201102018